Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles

Tetrabutylammonium Bromide System

Vapor-liquid equilibrium and density measurements have been performed on 1.00-5.89 m tetrabutylammonium bromide (TBAB) in mixtures of 2-propanoland water. The VLE experiments were performed using a modified Othmer still a t ambient pressure. The effect of salt on the relative volatility of 2-propanol was evaluated at molalities of 1.00,1.79, and 5.89 over the full range of solvent composition. ...

Synthesis of heterocycles via palladium-catalyzed carbonylations.

Unconventional synthesis of nitrogenated heterocycles with potencial bioactive properties

Introduction In recent years, a new approach called “Green Chemistry” emerged in the field of organic chemistry, to prevent or minimize contamination from the laboratory bench up to industrial production. It purpose is to avoid residue formation, saving time and costs. One of the strategies proposed for the existing products involves designing alternative synthesis steps that do not use toxic s...

Greener and expeditious synthesis of bioactive heterocycles using microwave irradiation

The utilization of green chemistry techniques is dramatically reducing chemical waste and reaction times as has recently been proven in several organic syntheses and chemical transformations. To illustrate these advantages in the synthesis of bioactive heterocycles, we have studied various environmentally benign protocols that involve greener alternatives. Microwave (MW) irradiation of neat rea...

Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature

The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various a...